Select how often (in days) to receive an alert:
Senior Scientist, non-clinical & clinical PK/PD Modeling and Simulation

Mission

Lead the implementation of currently unavailable M&S tools & capabilities within the company.
Engage proactively in discovery and development projects with M&S needs for NCEs, NBEs or other drug modalities in a multidisciplinary environment.
Devise the PK/PD strategy and use of M&S to support the design of in-vitro/in-vivo mechanistic studies.
Deliver PK, PK/PD or PBPK modelling to support the optimization of drug candidates in preclinical projects of different modalities.
Strong interaction with translational medicine and clinical teams to guide dose selection.
Human PK predictions to estimate efficacious exposure/dose and support the clinical development program (e.g. Pop PK & ER).
Balance the needs of M&S in R&D projects according to available internal capabilities or through outsourcing to pharmacometric CROs.
Provide M&S support/review for IND / NDA / BLA submissions.
Foster a continuous update of scientific M&S knowledge to keep up high standards within the Company.
Education

Bachelor of Science, Master of Science or Ph D (Ph D degree in a field related to pharmacometrics is preferable) in either Pharmacokinetics, Pharmacology, Pharmaceutical/Biotechnological Sciences, Biomedical/Chemical Engineering, Applied Mathematics, or a health-related discipline.
Specific Knowledge

Good understanding of translational medicine aspects to connect preclinical and Clinical DMPK.
Comprehensive understanding of the concepts of pharmacokinetics and pharmacodynamics during drug discovery & development.
Good understanding of the Principles for Model-Informed Drug Development.
Proven skills in PK, PK/PD, PBPK and/or longitudinal disease modelling.
Proficiency and extensive hands-on experience with modeling software such as MATLAB, R, Phoenix, or NONMEM, among others.
Experience

At least 5 years of experience in the field (preferably in an industrial environment).
Teamwork and personal leadership.
Ability to work in a matrix environment, multi-task, meet deadlines and deal with evolving priorities.
Strategic thinker with leadership skills and the ability to work collaboratively across various teams and disciplines.
Capable of building and maintaining professional networks to support collaborative efforts.
Fluent in both oral and written English, essential for effective communication and documentation.
Values

Care: we listen & empathize, we value diverse perspectives & backgrounds and we help each other succeed.
Courage: we challenge the status quo, we take full ownership and we learn from our success & failures.
Innovation: we put the patient and customer at the center, we create novel solutions and we empower entrepreneurial mindsets.
Simplicity: we act decisively and avoid over-analysis, we understand why before we act and we are agile & keep things simple.

#J-18808-Ljbffr